Introduction | First we load the libraries | Download data from GEO | Age*stage effect modification analysis | Compute BH FDR | Repeatly conduct analysis following permutation | Compute FDR using the fdrci package | First we will estimate FDR and 95% CIs without accounting for multiplicity | Next we use the BH option for the FDR selection and adjustment approach described in our paper [@JM-BY-FDR]. | Why is there no difference between the adjusted and unadjusted results? | Final thoughts